CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.460 | Monomethylamine methyltransferase MtmB |
Domain Context
CATH Clusters
| Superfamily | Monomethylamine methyltransferase MtmB |
| Functional Family | Monomethylamine methyltransferase MtmB1 |
Enzyme Information
| 2.1.1.248 |
[Methylamine--corrinoid protein] Co-methyltransferase.
based on mapping to UniProt O30642
Methylamine + a [Co(I) methylamine-specific corrinoid protein] = a [methyl-Co(III) methylamine-specific corrinoid protein] + ammonia.
-!- The enzyme, which catalyzes the transfer of a methyl group from methylamine to a methylamine-specific corrinoid protein (MtmC), is involved in methanogenesis from methylamine. -!- The enzyme contains the unusual amino acid pyrrolysine. -!- Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. -!- During methylation the cobalt is oxidized to the Co(III) state. -!- The methylated corrinoid protein is substrate for EC 2.1.1.247.
|
UniProtKB Entries (1)
| O30642 |
MTMB1_METBA
Methanosarcina barkeri
Monomethylamine methyltransferase MtmB1
|
PDB Structure
| PDB | 1TV2 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Reactivity and chemical synthesis of L-pyrrolysine- the 22(nd) genetically encoded amino acid
Chem.Biol.
|
