CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.10 | Ribbon |
|
2.10.70 | Complement Module; domain 1 |
|
2.10.70.10 | Complement Module, domain 1 |
Domain Context
CATH Clusters
| Superfamily | Complement Module, domain 1 |
| Functional Family | Plasminogen activator |
Enzyme Information
| 3.4.21.68 |
T-plasminogen activator.
based on mapping to UniProt P00750
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
-!- From a wide variety of mammalian tissues, especially endothelial cells. -!- Secreted as a single chain precursor which is cleaved to a two-chain form by plasmin. -!- Activity is considerably enhanced by fibrin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.21.31 and EC 3.4.99.26.
|
UniProtKB Entries (1)
| P00750 |
TPA_HUMAN
Homo sapiens
Tissue-type plasminogen activator
|
PDB Structure
| PDB | 1TPM |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Solution structure of the fibrin binding finger domain of tissue-type plasminogen activator determined by 1H nuclear magnetic resonance.
J.Mol.Biol.
|
