CATH Classification

Domain Context

CATH Clusters

Superfamily Plasminogen Kringle 4
Functional Family Urokinase-type plasminogen activator

Enzyme Information

3.4.21.68
T-plasminogen activator.
based on mapping to UniProt P00750
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
-!- From a wide variety of mammalian tissues, especially endothelial cells. -!- Secreted as a single chain precursor which is cleaved to a two-chain form by plasmin. -!- Activity is considerably enhanced by fibrin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.21.31 and EC 3.4.99.26.

UniProtKB Entries (1)

P00750
TPA_HUMAN
Homo sapiens
Tissue-type plasminogen activator

PDB Structure

PDB 1TPK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution.
de Vos, A.M., Ultsch, M.H., Kelley, R.F., Padmanabhan, K., Tulinsky, A., Westbrook, M.L., Kossiakoff, A.A.
Biochemistry