CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.10 | Thrombin, subunit H |
|
2.40.10.10 | Trypsin-like serine proteases |
Domain Context
CATH Clusters
| Superfamily | Trypsin-like serine proteases |
| Functional Family | Prothrombin |
Enzyme Information
| 3.4.21.5 |
Thrombin.
based on mapping to UniProt P00735
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.
|
UniProtKB Entries (2)
| P56409 |
ORNT_ORNMO
Ornithodoros moubata
Ornithodorin
|
| P00735 |
THRB_BOVIN
Bos taurus
Prothrombin
|
PDB Structure
| PDB | 1TOC |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The ornithodorin-thrombin crystal structure, a key to the TAP enigma?
EMBO J.
|
