CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.390 | Neutral Protease; domain 2 | |
1.10.390.10 | Neutral Protease Domain 2 |
Domain Context
CATH Clusters
Superfamily | Neutral Protease Domain 2 |
Functional Family | Thermolysin |
Enzyme Information
3.4.24.27 |
Thermolysin.
based on mapping to UniProt P00800
Preferential cleavage: Xaa-|-Leu > Xaa-|-Phe.
-!- A thermostable extracellular metalloendopeptidase containing four calcium ions. -!- Enzymes that may be species variants of thermolysin are reported from Micrococcus caseolyticus and Aspergillus oryzae. -!- Closely related but distinct enzymes are aeromonolysin, pseudolysin, bacillolysin, aureolysin and mycolysin. -!- Belongs to peptidase family M4. -!- Formerly EC 3.4.24.4.
|
UniProtKB Entries (1)
P00800 |
THER_BACTH
Bacillus thermoproteolyticus
Thermolysin
|
PDB Structure
PDB | 1TLP |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystallographic structural analysis of phosphoramidates as inhibitors and transition-state analogs of thermolysin.
Eur.J.Biochem.
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