CATH Domain 1thmA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.200	Peptidase S8/S53 domain

Domain Context

CATH Clusters

Superfamily	Peptidase S8/S53 domain
Functional Family

Enzyme Information

3.4.21.66

Thermitase.

based on mapping to UniProt P04072

Hydrolysis of proteins, including collagen.

-!- From Thermoactinomyces vulgaris containing a single Cys, near the active site His, and inhibited by p-mercuribenzoate. -!- The N-terminal extension of the polypeptide chain relative to subtilisin contributes to calcium-binding and the high thermostability. -!- The amino acid composition and properties of the thermostable enzyme from Streptomyces rectus var. proteolyticus are closely similar. -!- Belongs to peptidase family S8. -!- Formerly EC 3.4.4.16.

UniProtKB Entries (1)

P04072

THET_THEVU

Thermoactinomyces vulgaris

Thermitase

PDB Structure

PDB	1THM
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of thermitase at 1.4 A resolution. Teplyakov, A.V., Kuranova, I.P., Harutyunyan, E.H., Vainshtein, B.K., Frommel, C., Hohne, W.E., Wilson, K.S. J.Mol.Biol.