CATH Domain 1ta2A01

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Superfamily	Trypsin-like serine proteases
Functional Family	Prothrombin

3.4.21.5

Thrombin.

based on mapping to UniProt P00734

Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.

-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

P00734	THRB_HUMAN Homo sapiens Prothrombin
P28504	HIR2_HIRME Hirudo medicinalis Hirudin-2

PDB	1TA2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Design and synthesis of a series of potent and orally bioavailable noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 position Tucker, T.J., Brady, S.F., Lumma, W.C., Lewis, S.D., Gardel, S.J., Naylor-Olsen, A.M., Yan, Y., Sisko, J.T., Stauffer, K.J., Lucas, B.Y., Lynch, J.J., Cook, J.J., Stranieri, M.T., Holahan, M.A., Lyle, E.A., Baskin, E.P., Chen, I.-W., Dancheck, K.B., Krueger, J.A., Cooper, C.M., Vacca, J.P. J.Med.Chem.