CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.150 | DNA polymerase; domain 1 |
|
1.10.150.20 | 5' to 3' exonuclease, C-terminal subdomain |
Domain Context
CATH Clusters
| Superfamily | 5' to 3' exonuclease, C-terminal subdomain |
| Functional Family | DNA polymerase iota |
Enzyme Information
| 2.7.7.7 |
DNA-directed DNA polymerase.
based on mapping to UniProt Q9UNA4
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
|
UniProtKB Entries (1)
| Q9UNA4 |
POLI_HUMAN
Homo sapiens
DNA polymerase iota
|
PDB Structure
| PDB | 1T3N |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Saccharomyces |
| Primary Citation |
Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing.
Nature
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