CATH Domain 1t3eA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.105	Molybdopterin biosynthesis moea protein, domain 2
	3.90.105.10	Molybdopterin biosynthesis moea protein, domain 2

Domain Context

CATH Clusters

Superfamily	Molybdopterin biosynthesis moea protein, domain 2
Functional Family	Molybdopterin molybdenumtransferase

Enzyme Information

2.7.7.75

Molybdopterin adenylyltransferase.

based on mapping to UniProt Q03555

ATP + molybdopterin = diphosphate + adenylyl-molybdopterin.

-!- Catalyzes the activation of molybdopterin for molybdenum insertion. -!- In eukaryotes, this reaction is catalyzed by the C-terminal domain of a fusion protein that also includes molybdopterin molybdotransferase (EC 2.10.1.1). -!- The reaction requires a divalent cation such as Mg(2+) or Mn(2+). -!- Catalyzes the activation of molybdopterin for molybdenum insertion. -!- In eukaryotes, this reaction is catalyzed by the C-terminal domain of a fusion protein that also includes EC 2.10.1.1. -!- Formerly EC 2.7.7.n5.

2.10.1.1

Molybdopterin molybdotransferase.

based on mapping to UniProt Q03555

Adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP.

-!- Catalyzes the insertion of molybdenum into the ene-dithiol group of molybdopterin. -!- In eukaryotes this reaction is catalyzed by the N-terminal domain of a fusion protein whose C-terminal domain catalyzes EC 2.7.7.75.

UniProtKB Entries (1)

P20781

GLRB_RAT

Rattus norvegicus

Glycine receptor subunit beta

PDB Structure

PDB	1T3E
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structural basis of dynamic glycine receptor clustering by gephyrin Sola, M., Bavro, V.N., Timmins, J., Franz, T., Ricard-Blum, S., Schoehn, G., Ruigrok, R.W.H., Paarmann, I., Saiyed, T., O'Sullivan, G.A., Schmitt, B., Betz, H., Weissenhorn, W. Embo J.