CATH Domain 1t2pA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.260	Sortase; Chain: A;
	2.40.260.10	Sortase

Domain Context

CATH Clusters

Superfamily	Sortase
Functional Family	Class A sortase SrtA

Enzyme Information

3.4.22.70

Sortase A.

based on mapping to UniProt Q9S446

The enzyme catalyzes a cell wall sorting reaction in which a surface protein with a sorting signal containing a LPXTG motif is cleaved between the Thr and Gly residue. The resulting threonine carboxyl end of the protein is covalently attached to a pentaglycine cross-bridge of peptidoglycan.

-!- Belongs to peptidase family C60.

UniProtKB Entries (1)

Q9S446

Q9S446_STAAU

Staphylococcus aureus

Class A sortase SrtA

PDB Structure

PDB	1T2P
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	CRYSTAL STRUCTURES OF STAPHYLOCOCCUS AUREUS SORTASE A AND ITS SUBSTRATE COMPLEX Zong, Y., Bice, T.W., Ton-That, H., Schneewind, O., Narayana, S.V. J.Biol.Chem.