CATH Domain 1sz6B01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.80	Trefoil
	2.80.10	Trefoil (Acidic Fibroblast Growth Factor, subunit A)
	2.80.10.50

Domain Context

CATH Clusters

Superfamily	2.80.10.50
Functional Family	Beta-galactoside-specific lectin 1

Enzyme Information

3.2.2.22

rRNA N-glycosylase.

based on mapping to UniProt P81446

Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.

-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P81446

ML1_VISAL

Viscum album

Beta-galactoside-specific lectin 1

PDB Structure

PDB	1SZ6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of Viscum album Mistletoe Lectin I in native state at 2.05 A resolution, comparison of structure active site conformation in ricin and in viscumin Gabdoulkhakov, A.G., Guhlistova, N.E., Lyashenko, A.V., Krauspenhaar, R., Stoeva, S., Voelter, W., Nikonov, S.V., Betzel, C., Mikhailov, A.M. TO BE PUBLISHED