CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.1.1.27
L-lactate dehydrogenase.
based on mapping to UniProt Q27797
(S)-lactate + NAD(+) = pyruvate + NADH.
-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.

UniProtKB Entries (1)

Q27797
LDH_TOXGO
Toxoplasma gondii
L-lactate dehydrogenase

PDB Structure

PDB 1SOW
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of apo and ternary forms of Toxoplasma gondii LDH2
Kavanagh, K.L., Wilson, D.K.
To be Published