CATH Classification

Domain Context

CATH Clusters

Superfamily Serralysin-like metalloprotease, C-terminal
Functional Family Serralysin

Enzyme Information

3.4.24.40
Serralysin.
based on mapping to UniProt P23694
Preferential cleavage of bonds with hydrophobic residues in P1'.
-!- An extracellular endopeptidase from Pseudomonas aeruginosa, Escherichia freundii, Serratia marcescens and Erwinia chrysanthemi. -!- There is broad specificity in cleavage of the insulin B chain, with some species variations. -!- The pH optimum for digesting various proteins is about 9-10. -!- Belongs to peptidase family M10A. -!- Formerly EC 3.4.24.4.

UniProtKB Entries (2)

P23694
PRZN_SERMA
Serratia marcescens
Serralysin
P18958
INH_DICCH
Dickeya chrysanthemi
Proteinase inhibitor

PDB Structure

PDB 1SMP
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of a complex between Serratia marcescens metallo-protease and an inhibitor from Erwinia chrysanthemi.
Baumann, U., Bauer, M., Letoffe, S., Delepelaire, P., Wandersman, C.
J.Mol.Biol.