CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.150 | DNA polymerase; domain 1 | |
1.10.150.20 | 5' to 3' exonuclease, C-terminal subdomain |
Domain Context
CATH Clusters
Superfamily | 5' to 3' exonuclease, C-terminal subdomain |
Functional Family |
Enzyme Information
3.1.11.- |
Exodeoxyribonucleases producing 5'-phosphomonoesters.
based on mapping to UniProt P00581
|
2.7.7.7 |
DNA-directed DNA polymerase.
based on mapping to UniProt P00581
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
|
UniProtKB Entries (2)
P0AA25 |
THIO_ECOLI
Escherichia coli K-12
Thioredoxin 1
|
P00581 |
DPOL_BPT7
Enterobacteria phage T7
DNA-directed DNA polymerase
|
PDB Structure
PDB | 1SKS |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Nucleotide insertion opposite a cis-syn thymine dimer by a replicative DNA polymerase from bacteriophage T7.
Nat.Struct.Mol.Biol.
|