CATH Domain 1skjA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.505	SHC Adaptor Protein
	3.30.505.10	SH2 domain

Domain Context

CATH Clusters

Superfamily	SH2 domain
Functional Family	Tyrosine-protein kinase

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P00524

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P00524

SRC_RSVSA

Rous sarcoma virus (strain Schmidt-Ruppin A)

Tyrosine-protein kinase transforming protein Src

PDB Structure

PDB	1SKJ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Design, synthesis, and cocrystal structure of a nonpeptide Src SH2 domain ligand. Plummer, M.S., Holland, D.R., Shahripour, A., Lunney, E.A., Fergus, J.H., Marks, J.S., McConnell, P., Mueller, W.T., Sawyer, T.K. J.Med.Chem.