CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.910 | Heme Oxygenase; Chain A |
|
1.20.910.10 | Heme oxygenase-like |
Domain Context
CATH Clusters
| Superfamily | Heme oxygenase-like |
| Functional Family | Heme oxygenase |
Enzyme Information
| 1.14.99.58 |
Heme oxygenase (biliverdin-IX-beta and delta-forming).
based on mapping to UniProt O69002
(1) Protoheme + 3 reduced acceptor + 3 O(2) = biliverdin-IX-delta + CO + Fe(2+) + 3 acceptor + 3 H(2)O. (2) Protoheme + 3 reduced acceptor + 3 O(2) = biliverdin-IX-beta + CO + Fe(2+) + 3 acceptor + 3 H(2)O.
-!- The enzyme, characterized from the bacterium Pseudomonas aeruginosa, differs from EC 1.14.15.20 in that the heme substrate is rotated by approximately 110 degrees within the active site, resulting in cleavage at a different part of the ring. -!- It forms a mixture of about 70% biliverdin-IX-delta and 30% biliverdin-IX-beta.
|
UniProtKB Entries (1)
| O69002 |
O69002_PSEAI
Pseudomonas aeruginosa
Biliverdin-producing heme oxygenase
|
PDB Structure
| PDB | 1SK7 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structural basis for novel delta-regioselective heme oxygenation in the opportunistic pathogen Pseudomonas aeruginosa
Biochemistry
|
