CATH Domain 1shwB00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.120	Jelly Rolls
	2.60.120.260	Galactose-binding domain-like

Domain Context

CATH Clusters

Superfamily	Galactose-binding domain-like
Functional Family	Ephrin type-B receptor 2

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P54763

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P54763

EPHB2_MOUSE

Mus musculus

Ephrin type-B receptor 2

PDB Structure

PDB	1SHW
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Homo
Primary Citation	Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling Himanen, J.P., Chumley, M.J., Lackmann, M., Li, C., Barton, W.A., Jeffrey, P.D., Vearing, C., Geleick, D., Feldheim, D.A., Boyd, A.W., Henkemeyer, M., Nikolov, D.B. Nat.Neurosci.