CATH Domain 1shdA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.505	SHC Adaptor Protein
	3.30.505.10	SH2 domain

Domain Context

CATH Clusters

Superfamily	SH2 domain
Functional Family	Tyrosine-protein kinase

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P12931

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P12931

SRC_HUMAN

Homo sapiens

Proto-oncogene tyrosine-protein kinase Src

PDB Structure

PDB	1SHD
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Peptide inhibitors of src SH3-SH2-phosphoprotein interactions. Gilmer, T., Rodriguez, M., Jordan, S., Crosby, R., Alligood, K., Green, M., Kimery, M., Wagner, C., Kinder, D., Charifson, P., Hassel, A.M., Willard, D., Luther, M., Rusnak, D., Sternbach, D.D., Mehrotra, M., Peel, M., Shampine, L., Davis, R., Robbins, J., Patel, I.R., Kassel, D., Burkhart, W., Moyer, M., Bradshaw, T., Berman, J. J.Biol.Chem.