CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.30 | Glutaredoxin | |
3.40.30.10 | Glutaredoxin |
Domain Context
CATH Clusters
Superfamily | Glutaredoxin |
Functional Family | Arsenate reductase |
Enzyme Information
1.20.4.1 |
Arsenate reductase (glutaredoxin).
based on mapping to UniProt P08692
Arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H(2)O.
-!- A molybdoenzyme. -!- The enzyme is part of a system for detoxifying arsenate. -!- Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by EC 7.3.2.7; in other organisms, arsenite can be methylated by EC 2.1.1.137 in a pathway that produces non-toxic organoarsenical compounds (cf. EC 1.20.4.4). -!- Formerly EC 1.97.1.5.
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UniProtKB Entries (1)
P08692 |
ARSC1_ECOLX
Escherichia coli
Arsenate reductase
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PDB Structure
PDB | 1SD9 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Arginine 60 in the ArsC arsenate reductase of E. coli plasmid R773 determines the chemical nature of the bound As(III) product.
Protein Sci.
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