CATH Classification

Domain Context

CATH Clusters

Superfamily Glutaredoxin
Functional Family Arsenate reductase

Enzyme Information

1.20.4.1
Arsenate reductase (glutaredoxin).
based on mapping to UniProt P08692
Arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H(2)O.
-!- A molybdoenzyme. -!- The enzyme is part of a system for detoxifying arsenate. -!- Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by EC 7.3.2.7; in other organisms, arsenite can be methylated by EC 2.1.1.137 in a pathway that produces non-toxic organoarsenical compounds (cf. EC 1.20.4.4). -!- Formerly EC 1.97.1.5.

UniProtKB Entries (1)

P08692
ARSC1_ECOLX
Escherichia coli
Arsenate reductase

PDB Structure

PDB 1SD9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Arginine 60 in the ArsC arsenate reductase of E. coli plasmid R773 determines the chemical nature of the bound As(III) product.
DeMel, S., Shi, J., Martin, P., Rosen, B.P., Edwards, B.F.
Protein Sci.