CATH Domain 1sc7A04

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.132	Topoisomerase I; Chain A, domain 4
	1.10.132.10

Domain Context

CATH Clusters

Superfamily	1.10.132.10
Functional Family	DNA topoisomerase I

Enzyme Information

5.6.2.2

DNA topoisomerase.

based on mapping to UniProt P11387

ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.

-!- These enzymes bring about the conversion of one topological isomer of DNA into another, e.g., the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences, cf. EC 5.6.2.3. -!- Formerly EC 5.99.1.2.

UniProtKB Entries (1)

P11387

TOP1_HUMAN

Homo sapiens

DNA topoisomerase 1

PDB Structure

PDB	1SC7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Spodoptera
Primary Citation	Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex Staker, B.L., Feese, M.D., Cushman, M., Pommier, Y., Zembower, D., Stewart, L., Burgin, A.B. J.Med.Chem.