CATH Classification

Domain Context

CATH Clusters

Superfamily 5' to 3' exonuclease, C-terminal subdomain
Functional Family DNA-directed RNA polymerase

Enzyme Information
DNA-directed RNA polymerase.
based on mapping to UniProt P00573
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC and EC

UniProtKB Entries (1)

Enterobacteria phage T7
T7 RNA polymerase

PDB Structure

PDB 1S76
External Links
Organism Escherichia
Primary Citation
The structural mechanism of translocation and helicase activity in T7 RNA polymerase.
Yin, Y.W., Steitz, T.A.