CATH Classification

Domain Context

CATH Clusters

Superfamily Divalent-metal-dependent TIM barrel enzymes
Functional Family Xylose isomerase

Enzyme Information

5.3.1.5
Xylose isomerase.
based on mapping to UniProt P15587
D-xylopyranose = D-xylulose.
-!- The enzyme catalyzes the interconversion of aldose and ketose sugars with broad substrate specificity. -!- The enzyme binds the closed form of its sugar substrate (in the case of glucose, only the alpha anomer) and catalyzes ring opening to generate a form of open-chain conformation that is coordinated to one of the metal sites. -!- Isomerization proceeds via a hydride-shift mechanism.

UniProtKB Entries (1)

P15587
XYLA_STROL
Streptomyces olivochromogenes
Xylose isomerase

PDB Structure

PDB 1S5N
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Xylose isomerase in substrate and inhibitor michaelis States: atomic resolution studies of a metal-mediated hydride shift(,).
Fenn, T.D., Ringe, D., Petsko, G.A.
Biochemistry