CATH Classification

Domain Context

CATH Clusters

Superfamily Hemopexin-like domain
Functional Family 72 kDa type IV collagenase

Enzyme Information

3.4.24.24
Gelatinase A.
based on mapping to UniProt P08253
Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln.
-!- Belongs to peptidase family M10B.

UniProtKB Entries (1)

P08253
MMP2_HUMAN
Homo sapiens
72 kDa type IV collagenase

PDB Structure

PDB 1RTG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The C-terminal (haemopexin-like) domain structure of human gelatinase A (MMP2): structural implications for its function.
Gohlke, U., Gomis-Ruth, F.X., Crabbe, T., Murphy, G., Docherty, A.J., Bode, W.
FEBS Lett.