CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.410 | von Willebrand factor, type A domain |
Domain Context
CATH Clusters
| Superfamily | von Willebrand factor, type A domain |
| Functional Family | Complement factor B |
Enzyme Information
| 3.4.21.47 |
Alternative-complement-pathway C3/C5 convertase.
based on mapping to UniProt P00751
Cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha- chain to yield C5a and C5b.
-!- A bimolecular complex of complement fragment Bb with either C3b or cobra venom factor; Bb contains the active site. -!- Bb is formed by cleavage of proenzyme factor B by factor D. -!- Cleavage of complement component C5 requires additional C3b which binds C5 and renders it susceptible to cleavage by C3b,Bb complex. -!- C3b,Bb is stabilized in plasma by factor P. -!- Belongs to peptidase family S1.
|
UniProtKB Entries (1)
| P00751 |
CFAB_HUMAN
Homo sapiens
Complement factor B
|
PDB Structure
| PDB | 1RS0 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Trichoplusia |
| Primary Citation |
Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase.
Mol.Cell
|