CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.450.60
Functional Family Lipoxygenase

Enzyme Information

1.13.11.58
Linoleate 9S-lipoxygenase.
based on mapping to UniProt P09186
Linoleate + O(2) = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate.
-!- A common plant lipoxygenase that oxidizes linoleate and alpha- linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C(9) position with (S)- configuration. -!- The enzyme plays a physiological role during the early stages of seedling growth. -!- The enzyme from Arabidopsis thaliana shows comparable activity toward linoleate and linolenate. -!- EC 1.13.11.12 catalyzes a similar reaction at another position of these fatty acids.

UniProtKB Entries (1)

P09186
LOX3_SOYBN
Glycine max
Seed linoleate 9S-lipoxygenase-3

PDB Structure

PDB 1RRH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Effect of crystal freezing and small-molecule binding on internal cavity size in a large protein: X-ray and docking studies of lipoxygenase at ambient and low temperature at 2.0 A resolution.
Skrzypczak-Jankun, E., BORBULEVYCH, O.Y., ZAVODSZKY, M.I., BARANSKI, M.R., PADMANABHAN, K., PETRICEK, V., JANKUN, J.
Acta Crystallogr.,Sect.D