CATH Classification

Domain Context

CATH Clusters

Superfamily FAD/NAD(P)-binding domain
Functional Family Thiamine thiazole synthase, chloroplastic

Enzyme Information

2.4.2.60
Cysteine-dependent adenosine diphosphate thiazole synthase.
based on mapping to UniProt Q38814
NAD(+) + glycine + [ADP-thiazole synthase]-L-cysteine = nicotinamide + ADP-5-ethyl-4-methylthiazole-2-carboxylate + [ADP-thiazole synthase]- dehydroalanine + 3 H(2)O.
-!- This iron dependent enzyme, found in fungi, plants, and some archaea, is involved in the thiamine phosphate biosynthesis pathway. -!- It is a single turn-over enzyme since the cysteine residue is not regenerated in vivo. -!- The homologous enzyme in archaea (EC 2.4.2.59) uses sulfide as sulfur donor.

UniProtKB Entries (1)

Q38814
THI4_ARATH
Arabidopsis thaliana
Thiamine thiazole synthase, chloroplastic

PDB Structure

PDB 1RP0
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of the thiazole biosynthetic enzyme THI1 from Arabidopsis thaliana.
Godoi, P.H., Galhardo, R.S., Luche, D.D., Van Sluys, M.A., Menck, C.F., Oliva, G.
J.Biol.Chem.
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