CATH Classification
Level | CATH Code | Description |
---|---|---|
4 | Few Secondary Structures | |
4.10 | Irregular | |
4.10.375 | Lipoxygenase-1; domain 2 | |
4.10.375.10 | Lipoxygenase-1; Domain 2 |
Domain Context
CATH Clusters
Superfamily | Lipoxygenase-1; Domain 2 |
Functional Family | Lipoxygenase |
Enzyme Information
1.13.11.58 |
Linoleate 9S-lipoxygenase.
based on mapping to UniProt P09186
Linoleate + O(2) = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate.
-!- A common plant lipoxygenase that oxidizes linoleate and alpha- linolenate, the two most common polyunsaturated fatty acids in plants, by inserting molecular oxygen at the C(9) position with (S)- configuration. -!- The enzyme plays a physiological role during the early stages of seedling growth. -!- The enzyme from Arabidopsis thaliana shows comparable activity toward linoleate and linolenate. -!- EC 1.13.11.12 catalyzes a similar reaction at another position of these fatty acids.
|
UniProtKB Entries (1)
P09186 |
LOX3_SOYBN
Glycine max
Seed linoleate 9S-lipoxygenase-3
|
PDB Structure
PDB | 1ROV |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Interaction between non-heme iron of lipoxygenases and cumene hydroperoxide: basis for enzyme activation, inactivation, and inhibition
J.Am.Chem.Soc.
|