1 keywords

CATH Domain 1rkpA00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.1300 Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
Homologous Superfamily 1.10.1300.10 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Domain Context

CATH Clusters

Superfamily 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family Phosphodiesterase

Enzyme Information

3.1.4.35
3',5'-cyclic-GMP phosphodiesterase.
based on mapping to UniProt O76074
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

UniProtKB Entries (1)

O76074
PDE5A_HUMAN
Homo sapiens
CGMP-specific 3',5'-cyclic phosphodiesterase

PDB Structure

PDB 1RKP
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor IBMX suggest a conformation determinant of inhibitor selectivity
Huai, Q., Liu, Y., Francis, S.H., Corbin, J.D., Ke, H.
J.Biol.Chem.