CATH Domain 1rjoA03

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.70	Distorted Sandwich
	2.70.98	Beta-galactosidase; Chain A, domain 5
	2.70.98.20	Copper amine oxidase, catalytic domain

Domain Context

CATH Clusters

Superfamily	Copper amine oxidase, catalytic domain
Functional Family	Amine oxidase

Enzyme Information

1.4.3.21

Primary-amine oxidase.

based on mapping to UniProt P46881

RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).

-!- A group of enzymes that oxidize primary monoamines but have little or no activity toward diamines, such as histamine, or toward secondary and tertiary amines. -!- They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. -!- In some mammalian tissues the enzyme also functions as a vascular- adhesion protein (VAP-1). -!- Formerly EC 1.4.3.6.

UniProtKB Entries (1)

P46881

PAOX_ARTGO

Arthrobacter globiformis

Phenylethylamine oxidase

PDB Structure

PDB	1RJO
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Using Xenon as a Probe for Dioxygen-binding Sites in Copper Amine Oxidases Duff, A.P., Trambaiolo, D.M., Cohen, A.E., Ellis, P.J., Juda, G.A., Shepard, E.M., Langley, D.B., Dooley, D.M., Freeman, H.C., Guss, J.M. J.Mol.Biol.