CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.70 | Alpha-Beta Plaits | |
3.30.70.1550 | Archaeal tRNA CCA-adding enzyme catalytic domain |
Domain Context
CATH Clusters
Superfamily | Archaeal tRNA CCA-adding enzyme catalytic domain |
Functional Family |
Enzyme Information
2.7.7.72 |
CCA tRNA nucleotidyltransferase.
based on mapping to UniProt O28126
A tRNA precursor + 2 CTP + ATP = a tRNA with a 3' CCA end + 3 diphosphate.
-!- The acylation of all tRNAs with an amino acid occurs at the terminal ribose of a 3' CCA sequence. -!- The CCA sequence is added to the tRNA precursor by stepwise nucleotide addition performed by a single enzyme that is ubiquitous in all living organisms. -!- Although the enzyme has the option of releasing the product after each addition, it prefers to stay bound to the product and proceed with the next addition. -!- Formerly EC 2.7.7.21 and EC 2.7.7.25.
|
UniProtKB Entries (1)
O28126 |
CCA_ARCFU
Archaeoglobus fulgidus DSM 4304
CCA-adding enzyme
|
PDB Structure
PDB | 1R89 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Crystal structures of an archaeal class I CCA-adding enzyme and its nucleotide complexes
Mol.Cell
|