CATH Classification

Domain Context

CATH Clusters

Superfamily SH3 Domains
Functional Family

Enzyme Information

3.4.24.75
Lysostaphin.
based on mapping to UniProt O05156
Hydrolysis of the -Gly-|-Gly- bond in the pentaglycine inter-peptide link joining staphylococcal cell wall peptidoglycans.
-!- Lyses cells of Staphylococcus aureus in particular, by its action on the cross-bridge of the cell wall. -!- Belongs to peptidase family M23.

UniProtKB Entries (1)

O05156
ALE1_STACP
Staphylococcus capitis
Glycyl-glycine endopeptidase ALE-1

PDB Structure

PDB 1R77
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Cell Wall-targeting Domain of Glycylglycine Endopeptidase Distinguishes among Peptidoglycan Cross-bridges.
Lu, J.Z., Fujiwara, T., Komatsuzawa, H., Sugai, M., Sakon, J.
J.Biol.Chem.
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