CATH Classification

Domain Context

CATH Clusters

Superfamily Microbial ribonucleases
Functional Family

Enzyme Information

3.1.27.10
rRNA endonuclease.
based on mapping to UniProt P00655
Hydrolysis of the phosphodiester linkage between guanosine and adenosine residues at one specific position in 28S rRNA from rat ribosomes.
-!- Also acts on bacterial rRNA.

UniProtKB Entries (1)

P00655
RNAS_ASPGI
Aspergillus giganteus
Ribonuclease alpha-sarcin

PDB Structure

PDB 1R4Y
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
NMR structure of the noncytotoxic {alpha}-sarcin mutant {Delta}(7-22): The importance of the native conformation of peripheral loops for activity.
Garcia-Mayoral, M.F., Garcia-Ortega, L., Lillo, M.P., Santoro, J., Martinez Del Pozo, A., Gavilanes, J.G., Rico, M., Bruix, M.
Protein Sci.
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