CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Glycogen synthase kinase-3 beta

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P49841
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
2.7.11.26
[Tau protein] kinase.
based on mapping to UniProt P49841
ATP + [tau protein] = ADP + [tau protein] phosphate.
-!- Activated by tubulin. -!- Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease. -!- Formerly EC 2.7.1.135.

UniProtKB Entries (1)

P49841
GSK3B_HUMAN
Homo sapiens
Glycogen synthase kinase-3 beta

PDB Structure

PDB 1R0E
External Links
Method X-RAY DIFFRACTION
Organism Trichoplusia
Primary Citation
From genetics to therapeutics: the Wnt pathway and osteoporosis
Allard, J., Nikolcheva, T., Gong, L., Wang, J., Dunten, P., Avnur, Z., Waters, R., Sun, Q., Skinner, B.
To be Published