CATH Domain 1qvxA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.120	Four Helix Bundle (Hemerythrin (Met), subunit A)
	1.20.120.330	Nucleotidyltransferases domain 2

Domain Context

CATH Clusters

Superfamily	Nucleotidyltransferases domain 2
Functional Family	focal adhesion kinase 1 isoform X1

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt Q00944

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q00944

FAK1_CHICK

Gallus gallus

Focal adhesion kinase 1

PDB Structure

PDB	1QVX
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism	Escherichia
Primary Citation	NMR Solution Structure of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase in Complex with a Paxillin LD Peptide: EVIDENCE FOR A TWO-SITE BINDING MODEL. Gao, G., Prutzman, K.C., King, M.L., Scheswohl, D.M., DeRose, E.F., London, R.E., Schaller, M.D., Campbell, S.L. J.Biol.Chem.