CATH Domain 1qqp200

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.120	Jelly Rolls
	2.60.120.20

Domain Context

CATH Clusters

Superfamily	2.60.120.20
Functional Family	Genome polyprotein

Enzyme Information

2.7.7.48	RNA-directed RNA polymerase. based on mapping to UniProt P03305 Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). -!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6.
3.6.1.15	Nucleoside-triphosphate phosphatase. based on mapping to UniProt P03305 NTP + H(2)O = NDP + phosphate. -!- The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria. -!- Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD. -!- The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
3.4.22.46	L-peptidase. based on mapping to UniProt P03305 Autocatalytically cleaves itself from the polyprotein of the foot- and-mouth disease virus by hydrolysis of a Lys-\|-Gly bond, but then cleaves host cell initiation factor eIF-4G at bonds -Gly-\|-Arg- and -Lys-\|-Arg-. -!- Best known from foot-and-mouth disease virus, but occurs in other aphthoviruses and cardioviruses. -!- Destruction of initiation factor eIF-4G has the effect of shutting off host-cell protein synthesis while allowing synthesis of viral proteins to continue. -!- The tertiary structure reveals a distant relationship to papain and, consistent with this, compound E-64 is inhibitory. -!- Belongs to peptidase family C28.
3.4.22.28	Picornain 3C. based on mapping to UniProt P03305 Selective cleavage of Gln-\|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly. -!- From entero-, rhino-, aphto- and cardioviruses. -!- Larger than the homologous virus picornain 2A. -!- Belongs to peptidase family C3.

UniProtKB Entries (1)

POLG_FMDVO

Foot-and-mouth disease virus (strain O1)

Genome polyprotein

PDB Structure

PDB	1QQP
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The structure and function of a foot-and-mouth disease virus-oligosaccharide receptor complex. Fry, E.E., Lea, S.M., Jackson, T., Newman, J.W., Ellard, F.M., Blakemore, W.E., Abu-Ghazaleh, R., Samuel, A., King, A.M., Stuart, D.I. EMBO J.