CATH Domain 1qpfD00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.50	Chitinase A; domain 3
	3.10.50.40

Domain Context

CATH Clusters

Superfamily	3.10.50.40
Functional Family	Peptidyl-prolyl cis-trans isomerase FKBP1A

Enzyme Information

5.2.1.8

Peptidylprolyl isomerase.

based on mapping to UniProt P62942

Peptidylproline (omega=180) = peptidylproline (omega=0).

-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P62942

FKB1A_HUMAN

Homo sapiens

Peptidyl-prolyl cis-trans isomerase FKBP1A

PDB Structure

PDB	1QPF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	32-Indolyl ether derivatives of ascomycin: three-dimensional structures of complexes with FK506-binding protein. Becker, J.W., Rotonda, J., Cryan, J.G., Martin, M., Parsons, W.H., Sinclair, P.J., Wiederrecht, G., Wong, F. J.Med.Chem.