CATH Classification

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family Vacuolar aspartic proteinase

Enzyme Information

3.4.23.40
Phytepsin.
based on mapping to UniProt P42210
Prefers hydrophobic residues Phe, Val, Ile, Leu, and Ala at P1 and P1', but also cleaves -Phe-|-Asp- and -Asp-|-Asp- bonds in 2S albumin from plant seeds.
-!- Known particularly fron barley grain, but present in other plants also. -!- Belongs to peptidase family A1.

UniProtKB Entries (1)

P42210
ASPR_HORVU
Hordeum vulgare
Phytepsin

PDB Structure

PDB 1QDM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of plant aspartic proteinase prophytepsin: inactivation and vacuolar targeting.
Kervinen, J., Tobin, G.J., Costa, J., Waugh, D.S., Wlodawer, A., Zdanov, A.
EMBO J.