CATH Classification
Domain Context
CATH Clusters
| Superfamily | 3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2 |
| Functional Family |
Enzyme Information
| 1.1.1.88 |
Hydroxymethylglutaryl-CoA reductase.
based on mapping to UniProt P13702
(R)-mevalonate + CoA + 2 NAD(+) = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH.
|
UniProtKB Entries (1)
| P13702 |
MVAA_PSEMV
Pseudomonas mevalonii
3-hydroxy-3-methylglutaryl-coenzyme A reductase
|
PDB Structure
| PDB | 1QAY |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Substrate-induced closure of the flap domain in the ternary complex structures provides insights into the mechanism of catalysis by 3-hydroxy-3-methylglutaryl-CoA reductase.
Proc.Natl.Acad.Sci.USA
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