CATH Domain 1qatA03

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.150	C2 domain

Domain Context

CATH Clusters

Superfamily	C2 domain
Functional Family	Phosphoinositide phospholipase C

Enzyme Information

3.1.4.11

Phosphoinositide phospholipase C.

based on mapping to UniProt P10688

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

-!- These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P(2) as well as Ins(1,4,5)P(3). -!- They show activity toward phosphatidylinositol, i.e., the activity of EC 4.6.1.13 in vitro at high calcium concentration.

UniProtKB Entries (1)

P10688

PLCD1_RAT

Rattus norvegicus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

PDB Structure

PDB	1QAT
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	C2 domain conformational changes in phospholipase C-delta 1. Grobler, J.A., Essen, L.O., Williams, R.L., Hurley, J.H. Nat.Struct.Biol.