CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.559 | Chloramphenicol Acetyltransferase |
|
3.30.559.30 | Nonribosomal peptide synthetase, condensation domain |
Domain Context
CATH Clusters
| Superfamily | Nonribosomal peptide synthetase, condensation domain |
| Functional Family |
Enzyme Information
| 2.3.1.282 |
Phenolphthiocerol/phthiocerol/phthiodiolone dimycocerosyl transferase.
based on mapping to UniProt P9WIN5
(1) 2 a mycocerosyl-[mycocerosic acid synthase] + a phthiocerol = a dimycocerosyl phthiocerol + 2 holo-[mycocerosic acid synthase]. (2) 2 a mycocerosyl-[mycocerosic acid synthase] + a phthiodiolone = a dimycocerosyl phthiodiolone + 2 holo-[mycocerosic acid synthase]. (3) 2 a mycocerosyl-[mycocerosic acid synthase] + a phenolphthiocerol = a dimycocerosyl phenolphthiocerol + 2 holo-[mycocerosic acid synthase].
-!- The enzyme, present in certain pathogenic species of mycobacteria, catalyzes the transfer of mycocerosic acids to the two hydroxyl groups at the common lipid core of phthiocerol, phthiodiolone, and phenolphthiocerol, forming dimycocerosate esters. -!- The fatty acid precursors of mycocerosic acids are activated by EC 6.2.1.49, which loads them onto EC 2.3.1.111. -!- That enzyme extends the precursors to form mycocerosic acids that remain attached until transferred by EC 2.3.1.282.
|
UniProtKB Entries (1)
| P9WIN5 |
PAPA5_MYCTU
Mycobacterium tuberculosis H37Rv
Phthiocerol/phthiodiolone dimycocerosyl transferase
|
PDB Structure
| PDB | 1Q9J |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal Structure of PapA5, a Phthiocerol Dimycocerosyl Transferase from Mycobacterium tuberculosis
J.Biol.Chem.
|
