CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.70 | Alpha-Beta Plaits |
|
3.30.70.590 | Poly(A) polymerase predicted RNA binding domain |
Domain Context
CATH Clusters
| Superfamily | Poly(A) polymerase predicted RNA binding domain |
| Functional Family | Putative poly(A) polymerase gamma |
Enzyme Information
| 2.7.7.19 |
Polynucleotide adenylyltransferase.
based on mapping to UniProt P25500
ATP + RNA(n) = diphosphate + RNA(n+1).
-!- Also acts slowly with CTP. -!- Catalyzes template-independent extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- The primer, depending on the source of the enzyme, may be an RNA or DNA fragment or oligo(A) bearing a 3'-OH terminal group. -!- See also EC 2.7.7.6.
|
UniProtKB Entries (1)
| P25500 |
PAPOA_BOVIN
Bos taurus
Poly(A) polymerase alpha
|
PDB Structure
| PDB | 1Q78 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Biochemical and structural insights into substrate binding and catalytic mechanism of mammalian poly(A) polymerase.
J.Mol.Biol.
|
