CATH Classification
Level | CATH Code | Description |
---|---|---|
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3 | Alpha Beta |
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3.30 | 2-Layer Sandwich |
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3.30.200 | Phosphorylase Kinase; domain 1 |
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3.30.200.20 | Phosphorylase Kinase; domain 1 |
Domain Context
CATH Clusters
Superfamily | Phosphorylase Kinase; domain 1 |
Functional Family | Glycogen synthase kinase-3 beta |
Enzyme Information
2.7.11.1 |
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P49841
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
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2.7.11.26 |
[Tau protein] kinase.
based on mapping to UniProt P49841
ATP + [tau protein] = ADP + [tau protein] phosphate.
-!- Activated by tubulin. -!- Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease. -!- Formerly EC 2.7.1.135.
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UniProtKB Entries (1)
P49841 |
GSK3B_HUMAN
Homo sapiens
Glycogen synthase kinase-3 beta
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PDB Structure
PDB | 1Q5K |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Trichoplusia |
Primary Citation |
Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418.
J.Biol.Chem.
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