CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.12 | Lyase 2-enoyl-coa Hydratase; Chain A, domain 2 |
|
1.10.12.10 | Lyase 2-enoyl-coa Hydratase, Chain A, domain 2 |
Domain Context
CATH Clusters
| Superfamily | Lyase 2-enoyl-coa Hydratase, Chain A, domain 2 |
| Functional Family | 1,4-dihydroxy-2-naphthoyl-CoA synthase |
Enzyme Information
| 4.1.3.36 |
1,4-dihydroxy-2-naphthoyl-CoA synthase.
based on mapping to UniProt P9WNP5
4-(2-carboxyphenyl)-4-oxobutanoyl-CoA = 1,4-dihydroxy-2-naphthoyl-CoA + H(2)O.
-!- This enzyme is involved in the synthesis of 1,4-dihydroxy-2- naphthoate, a branch point metabolite leading to the biosynthesis of menaquinone (vitamin K(2), in bacteria), phylloquinone (vitamin K(1) in plants), and many plant pigments. -!- The coenzyme A group is subsequently removed from the product by EC 3.1.2.28.
|
UniProtKB Entries (1)
| P9WNP5 |
MENB_MYCTU
Mycobacterium tuberculosis H37Rv
1,4-dihydroxy-2-naphthoyl-CoA synthase
|
PDB Structure
| PDB | 1Q52 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of Mycobacterium tuberculosis MenB, a key enzyme in vitamin K2 biosynthesis.
J.Biol.Chem.
|
