CATH Domain 1q12A03

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.50	OB fold (Dihydrolipoamide Acetyltransferase, E2P)
	2.40.50.100	RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain

Domain Context

CATH Clusters

Superfamily	2.40.50.100
Functional Family	Maltose/maltodextrin import ATP-binding protein MalK

Enzyme Information

7.5.2.1

ABC-type maltose transporter.

based on mapping to UniProt P68187

ATP + H(2)O + maltose-[maltose-binding protein](Side 1) = ADP + phosphate + maltose(Side 2) + [maltose-binding protein](Side 1).

-!- An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. -!- The enzyme, found in bacteria, interacts with an extracytoplasmic substrate binding protein and mediates the import of maltose and maltose oligosaccharides. -!- Formerly EC 3.6.3.19.

UniProtKB Entries (1)

P68187

MALK_ECOLI

Escherichia coli K-12

Maltose/maltodextrin import ATP-binding protein MalK

PDB Structure

PDB	1Q12
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	A tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle Chen, J., Lu, G., Lin, J., Davidson, A.L., Quiocho, F.A. Mol.Cell