CATH Domain 1pwwA03

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.2030	Anthrax toxin lethal factor, domain 3, chain A
	1.10.2030.10	Anthrax toxin lethal factor, domain 3, chain A

Domain Context

CATH Clusters

Superfamily	Anthrax toxin lethal factor, domain 3, chain A
Functional Family

Enzyme Information

3.4.24.83

Anthrax lethal factor endopeptidase.

based on mapping to UniProt P15917

Preferred amino acids around the cleavage site can be denoted BBBBxHx-|-H, in which B denotes Arg or Lys, H denotes a hydrophobic amino acid, and x is any amino acid. The only known protein substrates are mitogen-activated protein (MAP) kinase kinases.

-!- From the bacterium Bacilus anthracis that causes anthrax. -!- One of three proteins that are collectively termed anthrax toxin. -!- Cleaves several MAP kinase kinases near their N-termini, preventing them from phosphorylating the downstream mitogen-activated protein kinases. -!- Belongs to peptidase family M34.

UniProtKB Entries (1)

P15917

LEF_BACAN

Bacillus anthracis

Lethal factor

PDB Structure

PDB	1PWW
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Bacillus
Primary Citation	The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor. Turk, B.E., Wong, T.Y., Schwarzenbacher, R., Jarrell, E.T., Leppla, S.H., Collier, R.J., Liddington, R.C., Cantley, L.C. Nat.Struct.Mol.Biol.