CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphatidylinositol (PI) phosphodiesterase
Functional Family 1-phosphatidylinositol phosphodiesterase

Enzyme Information

4.6.1.13
Phosphatidylinositol diacylglycerol-lyase.
based on mapping to UniProt P14262
1-phosphatidyl-1D-myo-inositol = 1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol.
-!- This enzyme is bacterial. -!- Activity is also found in animals, but this activity is due to the presence of EC 3.1.4.11. -!- Formerly EC 3.1.4.10.

UniProtKB Entries (1)

P14262
PLC_BACCE
Bacillus cereus
1-phosphatidylinositol phosphodiesterase

PDB Structure

PDB 1PTG
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of the phosphatidylinositol-specific phospholipase C from Bacillus cereus in complex with myo-inositol.
Heinz, D.W., Ryan, M., Bullock, T.L., Griffith, O.H.
EMBO J.
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