CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.10 | Roll |
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3.10.129 | Thiol Ester Dehydrase; Chain A |
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3.10.129.10 | Hotdog Thioesterase |
Domain Context
CATH Clusters
Superfamily | Hotdog Thioesterase |
Functional Family | Peroxisomal multifunctional enzyme type 2 |
Enzyme Information
4.2.1.119 |
Enoyl-CoA hydratase 2.
based on mapping to UniProt P22414
(3R)-3-hydroxyacyl-CoA = (2E)-2-enoyl-CoA + H(2)O.
-!- This enzyme catalyzes a hydration step in peroxisomal beta-oxidation. -!- The human multifunctional enzyme type 2 (MFE-2) is a 79000 Da enzyme composed of three functional units: (3R)-hydroxyacyl-CoA dehydrogenase, 2-enoyl-CoA hydratase 2 and sterol carrier protein 2-like units. -!- The enzymes from Aeromonas caviae and Arabidopsis thaliana are monofunctional enzymes. -!- 2-enoyl-CoA hydratase 3 from Candida tropicalis is a part from multifunctional enzyme type 2.
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1.1.1.n12 |
(3R)-hydroxyacyl-CoA dehydrogenase.
based on mapping to UniProt P22414
(R)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
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UniProtKB Entries (1)
P22414 |
FOX2_CANTR
Candida tropicalis
Peroxisomal hydratase-dehydrogenase-epimerase
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PDB Structure
PDB | 1PN2 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
A Two-domain Structure of One Subunit Explains Unique Features of Eukaryotic Hydratase 2.
J.Biol.Chem.
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