CATH Domain 1pkgA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P10721

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P10721

KIT_HUMAN

Homo sapiens

Mast/stem cell growth factor receptor Kit

PDB Structure

PDB	1PKG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Spodoptera
Primary Citation	Structure of a c-Kit Product Complex Reveals the Basis for Kinase Transactivation. Mol, C.D., Lim, K.B., Sridhar, V., Zou, H., Chien, E.Y.T., Sang, B.-C., Nowakowski, J., Kassel, D.B., Cronin, C.N., McRee, D.E. J.Biol.Chem.