CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.5 | Single alpha-helices involved in coiled-coils or other helix-helix interfaces |
|
1.20.5.680 | Single Helix bin |
Domain Context
CATH Clusters
| Superfamily | Single Helix bin |
| Functional Family |
Enzyme Information
| 7.2.4.5 |
Glutaconyl-CoA decarboxylase.
based on mapping to UniProt Q06700
4-carboxybut-2-enoyl-CoA + Na(+)(Side 1) = but-2-enoyl-CoA + CO(2) + Na(+)(Side 2).
-!- The enzyme from the bacterium Acidaminococcus fermentans is a biotinyl-protein, requires Na(+), and acts as a sodium pump. -!- Prior to the Na(+)-dependent decarboxylation, the carboxylate is transferred to biotin in a Na(+)-independent manner. -!- The conserved lysine, to which biotin forms an amide bond, is located 34 amino acids before the C-terminus, flanked on both sides by two methionine residues, which are conserved in every biotin-dependent enzyme.
|
UniProtKB Entries (1)
| Q06700 |
GCDA_ACIFV
Acidaminococcus fermentans DSM 20731
Glutaconyl-CoA decarboxylase subunit alpha
|
PDB Structure
| PDB | 1PIX |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of the carboxyltransferase subunit of the bacterial sodium ion pump glutaconyl-coenzyme A decarboxylase
Embo J.
|