CATH Domain 1pgjB03

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.5	Single alpha-helices involved in coiled-coils or other helix-helix interfaces
	1.20.5.320	6-Phosphogluconate Dehydrogenase, domain 3

Domain Context

CATH Clusters

Superfamily	6-Phosphogluconate Dehydrogenase, domain 3
Functional Family	6-phosphogluconate dehydrogenase, decarboxylating

Enzyme Information

1.1.1.44

Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating).

based on mapping to UniProt P31072

6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.

-!- The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. -!- Highly specific for NADP(+). -!- Cf. EC 1.1.1.343.

UniProtKB Entries (1)

P31072

6PGD_TRYBB

Trypanosoma brucei brucei

6-phosphogluconate dehydrogenase, decarboxylating

PDB Structure

PDB	1PGJ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	A 2.8 A resolution structure of 6-phosphogluconate dehydrogenase from the protozoan parasite Trypanosoma brucei: comparison with the sheep enzyme accounts for differences in activity with coenzyme and substrate analogues. Phillips, C., Dohnalek, J., Gover, S., Barrett, M.P., Adams, M.J. J.Mol.Biol.